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Analytical Methods for Therapeutic Drug Monitoring and Toxicology Q. Alan Xu, Timothy L. Madden
Publisher: Wiley

Alan Xu, English | 2011 | ISBN: 0470455616 | PDF | 520 pages | 5.7 MB Analytical Methods for Therapeutic Drug Monitorin. The introduction of methods This chapter introduces the reader to the application of MS to TDM and toxicology, the steps that should be considered during implementation, and the processes that should be implemented to assure continued quality. In this investigation a DBS analytical approach is developed for the routine monitoring of caffeine, used to treat Apnea of Prematurity (AoP) in neonates, that is, children less than 1 month old. Experience gained over more than 25 years from working in the clinical and forensic toxicological field contributed to the data presented (see Additional file 1). Advances in instrumental techniques [2] have enabled the analysis of DBS samples to be expanded to include therapeutic drug monitoring [3, 4], paediatric pharmacokinetic (PK) studies [5–8], and metabolite identification investigations [9, 10]. Analytical Methods for Therapeutic Drug Monitoring and Toxicology "Q. Thousands of methods are described for drug analysis but until recently most have relied upon analytical tools, such as spectrophotometry and immunoassay, that suffer from lack of specificity and sensitivity. Main areas of pharmaceutical sciences covered are Pharmaceutics and Pharmaceutical Technology, Pharmaceutical Chemistry & Pharmaceutical Analysis, Pharmacology & Toxicology and Pharmacognosy & Phytopharmaceuticals. Research and MarketsPosted on:22 Feb 11. Analytical Methods for Therapeutic Drug Monitoring and Toxicology Q. Research and Markets: Analytical Methods for Therapeutic Drug Monitoring and Toxicology Provides a Thorough Description of Method Validation and Results. Therapeutic drug monitoring is a branch of clinical chemistry that specializes in the measurement of medication levels in blood. This book is a compilation of summarized analytical methods designed to serve the needs of pharmacologists, toxicologists, and other allied health professionals involved the development, use, or monitoring of pharmaceuticals. Its main focus is on drugs with a narrow therapeutic range, i.e.